Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.52 |
| ▸ | KCNJ6 | P48051 | 7/20 | 0.52 |
| ▸ | KCNJ5 | P48544 | 7/20 | 0.52 |
| ▸ | KCNJ3 | P48549 | 7/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3185815 | 0.95 | KCNJ6 (0.57) | MAPK14MAPK13MAPK12MAPK11KCNJ6 | |
| SCHEMBL4470729 | 0.85 | KCNJ6 (0.43) | MAPK14MAPK13MAPK12MAPK11KCNJ6 | |
| SCHEMBL3389842 | 0.85 | KCNJ6 (0.51) | MAPK14MAPK13MAPK12MAPK11KCNJ6 | |
| SCHEMBL3174513 | 0.85 | KCNJ6 (0.43) | MAPK14MAPK13MAPK12MAPK11KCNJ6 | |
| SCHEMBL3174602 | 0.84 | KCNJ6 (0.44) | MAPK14MAPK13MAPK12MAPK11KCNJ6 | |
| SCHEMBL3176505 | 0.80 | KCNJ6 (0.56) | MAPK14KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL378881 | 0.79 | CDK8 (0.63) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL3176730 | 0.79 | CDK8 (0.46) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL3165072 | 0.79 | CDK8 (0.45) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL3184425 | 0.78 | KCNJ6 (0.57) | MAPK14KCNJ6KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |