Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 11/20 | 0.51 |
| ▸ | KCNJ5 | P48544 | 11/20 | 0.51 |
| ▸ | KCNJ3 | P48549 | 11/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3185815 | 0.87 | KCNJ6 (0.57) | KCNJ6KCNJ5KCNJ3CDK8MAPK14 | |
| SCHEMBL3174513 | 0.86 | KCNJ6 (0.43) | KCNJ6KCNJ5KCNJ3CDK8MAPK14 | |
| SCHEMBL4470729 | 0.85 | KCNJ6 (0.43) | KCNJ6KCNJ5KCNJ3BRAFCDK8 | |
| SCHEMBL3388865 | 0.85 | MAPK14 (0.52) | KCNJ6KCNJ5KCNJ3CDK8MAPK14 | |
| SCHEMBL1012856 | 0.82 | KCNJ6 (0.58) | KCNJ6KCNJ5KCNJ3BRAFMAPK14 | |
| SCHEMBL3390231 | 0.80 | CDK8 (0.50) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL378881 | 0.79 | CDK8 (0.63) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3174282 | 0.79 | CDK8 (0.52) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3165072 | 0.79 | CDK8 (0.45) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3185420 | 0.78 | KCNJ6 (0.56) | KCNJ6KCNJ5KCNJ3CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |