Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | CIT | O14578 | 1/20 | 0.32 |
| ▸ | MUSK | O15146 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | STK10 | O94804 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390161 | 0.93 | SMN1; SMN2 (0.34) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3388858 | 0.93 | MAPK14 (0.37) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3393250 | 0.88 | MAPK12 (0.40) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3388913 | 0.86 | MAPK14 (0.55) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3394279 | 0.83 | MALT1 (0.37) | MAPK14MAPK12MAPK13MAPK11ALDH1A1 | |
| SCHEMBL3422290 | 0.83 | MAPK14 (0.37) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3389727 | 0.81 | GBA1 (0.38) | MAPK14MAPK12MAPK13MAPK11ALDH1A1 | |
| SCHEMBL3392832 | 0.81 | BRAF (0.35) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3391110 | 0.81 | GBA1 (0.41) | — | |
| SCHEMBL3390664 | 0.81 | BRAF (0.35) | MAPK14MAPK12MAPK13MAPK11PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |