Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392832 | 0.95 | BRAF (0.35) | BRAFPTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3393250 | 0.93 | MAPK12 (0.40) | BRAFKDM4EPTK2BMAPK14MAPK13 | |
| SCHEMBL3394286 | 0.91 | LMNA (0.37) | BRAFKDM4EPTK2BMAPK14MAPK13 | |
| SCHEMBL3422290 | 0.90 | MAPK14 (0.37) | BRAFKDM4EPTK2BMAPK14MAPK13 | |
| SCHEMBL3392512 | 0.90 | PTK2B (0.36) | BRAFPTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3393200 | 0.90 | PTK2B (0.37) | PTK2BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3174404 | 0.89 | MAPK14 (0.38) | BRAFPTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3394251 | 0.89 | PTK2B (0.39) | BRAFKDM4EPTK2BMAPK14LMNA | |
| SCHEMBL3389398 | 0.89 | PTK2B (0.36) | BRAFPTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3389419 | 0.89 | ALDH1A1 (0.39) | KDM4EPTK2BMAPK14LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |