Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 3/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388916 | 0.93 | MAPK14 (0.38) | MAPK1GPR119TRPV1PTK2BMAPK14 | |
| SCHEMBL3388858 | 0.90 | MAPK14 (0.37) | GPR119TRPV1PTK2BMAPK14MAPK13 | |
| SCHEMBL3390664 | 0.88 | BRAF (0.35) | SMN1; SMN2MAPK1TRPV1PTK2BMAPK14 | |
| SCHEMBL3390159 | 0.86 | MAPK14 (0.48) | PTK2BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3392618 | 0.84 | MAPK14 (0.51) | PTK2BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3392832 | 0.83 | BRAF (0.35) | TRPV1PTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3393250 | 0.81 | MAPK12 (0.40) | SMN1; SMN2PTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3394286 | 0.79 | LMNA (0.37) | SMN1; SMN2MAPK1TRPV1PTK2BMAPK14 | |
| SCHEMBL3388913 | 0.79 | MAPK14 (0.55) | MAPK1PTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3422290 | 0.78 | MAPK14 (0.37) | SMN1; SMN2TRPV1PTK2BMAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |