Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.32 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390651 | 0.90 | SMO (0.37) | CDK8MAPK14HTTSMN1; SMN2KDM4E | |
| SCHEMBL3388899 | 0.89 | CDK8 (0.34) | CDK8MAPK14BRAFMAPK13MAPK12 | |
| SCHEMBL3390498 | 0.87 | RAB9A (0.36) | CDK8MAPK14ALDH1A1BRAFMAPK13 | |
| SCHEMBL3390273 | 0.87 | MAPK14 (0.34) | CDK8MAPK14NTRK1NTRK3NTRK2 | |
| SCHEMBL3390581 | 0.84 | P2RY12 (0.37) | MAPK14SMN1; SMN2ALDH1A1 | |
| SCHEMBL3392905 | 0.83 | SMO (0.39) | CDK8MAPK14HTTSMN1; SMN2KDM4E | |
| SCHEMBL3388924 | 0.82 | MAPK14 (0.49) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3393238 | 0.81 | MAPK14 (0.52) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3180430 | 0.78 | CDK8 (0.35) | CDK8MAPK14BRAFMAPK13MAPK12 | |
| SCHEMBL3390558 | 0.78 | MAPK13 (0.40) | MAPK14SMN1; SMN2KDM4EALDH1A1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |