Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 3/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390651 | 0.93 | SMO (0.37) | SMOMAPK14CDK8PTK2KDM4E | |
| SCHEMBL3180430 | 0.87 | CDK8 (0.35) | MAPK14CDK8PTK2BRAFMAPK13 | |
| SCHEMBL4602880 | 0.85 | MAPK14 (0.43) | MAPK14CDK8PTK2ALDH1A1MAPK13 | |
| SCHEMBL3388929 | 0.83 | CDK8 (0.34) | MAPK14CDK8KDM4EALDH1A1GAA | |
| SCHEMBL3392902 | 0.82 | MAPK14 (0.52) | MAPK14CDK8PTK2MAPK13MAPK12 | |
| SCHEMBL3391079 | 0.81 | RBP4 (0.35) | MAPK14CDK8PTK2P2RY12MAPK13 | |
| SCHEMBL3389956 | 0.80 | RAB9A (0.36) | MAPK14CDK8PTK2P2RY12KDM4E | |
| SCHEMBL3392557 | 0.80 | MAPK14 (0.54) | MAPK14CDK8PTK2MAPK13MAPK12 | |
| SCHEMBL3393213 | 0.80 | PTK2B (0.38) | MAPK14PTK2KDM4ESMN1; SMN2MAPK13 | |
| SCHEMBL3393224 | 0.79 | GBA1 (0.38) | MAPK14KDM4EALDH1A1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |