Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.31 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.31 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385022 | 0.78 | SMPD3 (0.35) | SMPD3 | |
| SCHEMBL3383971 | 0.76 | ROCK2 (0.46) | ROCK2 | |
| SCHEMBL3386142 | 0.74 | SMPD3 (0.30) | SMPD3ROCK2 | |
| SCHEMBL3386151 | 0.74 | SMPD3 (0.30) | SMPD3ROCK2 | |
| SCHEMBL13362993 | 0.72 | CNR2 (0.31) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL15819365 | 0.68 | EHMT2 (0.55) | KDM4EALDH1A1PDE3BPDE3AEHMT2 | |
| SCHEMBL17268512 | 0.67 | NTSR1 (0.49) | KDM4EALDH1A1PDE3BPDE3AEHMT2 | |
| SCHEMBL13362887 | 0.65 | — | — | |
| SCHEMBL15818634 | 0.65 | NTSR1 (0.55) | KDM4EALDH1A1PDE3BPDE3AEHMT2 | |
| SCHEMBL12335773 | 0.64 | NTSR1 (0.45) | KDM4EALDH1A1EHMT2EHMT1NTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |