Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14980614 | 0.96 | HSD17B10 (0.47) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL13078379 | 0.96 | HSD17B10 (0.47) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL24971199 | 0.92 | CXCR4 (0.58) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL13522068 | 0.88 | CXCR4 (0.52) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL845511 | 0.86 | HSD17B10 (0.57) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL22416418 | 0.85 | HSD17B10 (0.48) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL14980595 | 0.85 | CYP3A4 (0.39) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL29860764 | 0.84 | HSD17B10 (0.55) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL4783223 | 0.84 | ACE2 (0.54) | ALOX15TSHRMEN1KMT2APRMT6 | |
| SCHEMBL19619099 | 0.83 | HSD17B10 (0.47) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197080-A | Polyethylene glycol lipid and liposome modified by same, pharmaceutical composition containing liposome, preparation and application of pharmaceutical composition | 厦门赛诺邦格生物科技股份有限公司 | 2022-10-18 | — | — | CN | claimed |
| CN-113501796-B | Aminoethylated piperazine and preparation method thereof | 大连理工大学 | 2022-08-26 | — | — | CN | disclosed |
| CN-113477052-B | Aminoethylated piperazine, preparation method thereof, carbon dioxide absorbent and application thereof | 大连理工大学 | 2022-05-24 | — | — | CN | disclosed |
| WO-2022093817-A1 | MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS, AND METHODS OF MAKING AND USING SAME | YALE UNIVERSITY (US) | 2022-05-05 | — | — | WO | disclosed |
| CN-113501796-A | Aminoethylated piperazine and preparation method thereof | 大连理工大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-113477052-A | Aminoethylated piperazine, preparation method thereof, carbon dioxide absorbent and application thereof | 大连理工大学 | 2021-10-08 | — | — | CN | disclosed |
| EP-3267794-B1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2020-09-09 | — | — | EP | disclosed |
| US-10336721-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | YALE UNIVERSITY (US) | 2019-07-02 | — | — | US | disclosed |
| US-20180179176-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2018-06-28 | — | — | US | disclosed |
| WO-2016130968-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | YALE UNIVERSITY (US) | 2016-08-18 | — | — | WO | disclosed |
| US-20080096887-A1 | cell proliferation, such as cancer, inflammation, and angiogenesis; fungal infections; antimalaria; Heat hock protein 90 (HSP-90) inhibitor | SERENEX, INC. | 2008-04-24 | — | — | US | disclosed |
| US-7288571-B2 | Thyroid receptor ligands and method II | KARO BIO AB (SE) | 2007-10-30 | — | — | US | disclosed |
| US-7217447-B2 | Ink-jet recording sheet | FUJIFILM CORPORATION (JP) | 2007-05-15 | — | — | US | disclosed |
| US-6749651-B2 | PREVENT AND CONTROL ENGINE DEPOSITS, PARTICULARLY INTAKE VALVE DEPOSITS; IMPROVED COMPATIBILITY | CHEVRON ORONITE COMPANY LLC | 2004-06-15 | — | — | US | disclosed |
| US-6733551-B2 | BLENDING TOGETHER MANNICH CONDENSATION PRODUCT OF HIGH MOLECULAR WEIGHT ALKYL-SUBSTITUTED HYDROXYAROMATIC COMPOUND, AMINE AND ALDEHYDE, HYDROCARBYL-TERMINATED POLY(OXYALKYLENE) MONOOL, CARBOXYLIC ACID, AND SELECTED ANHYDRIDE | CHEVRON ORONITE COMPANY LLC | 2004-05-11 | — | — | US | disclosed |
| EP-1375629-A2 | A method of improving the compatibility of a fuel additive composition containing a Mannich condensation product | Chevron Oronite Company LLC (US) | 2004-01-02 | — | — | EP | disclosed |
| US-20040000089-A1 | Method of improving the compatibility of a fuel additive composition containing a mannich condensation product | CHEVRON ORONITE COMPANY LLC | 2004-01-01 | — | — | US | disclosed |
| US-20030172582-A1 | Fuel additive compositions containing a mannich condensation product, a poly (oxyalkylene) monool, and a carboxylic acid | CHEVRON ORONITE COMPANY LLC | 2003-09-18 | — | — | US | disclosed |
| EP-1323814-A2 | Fuel additive compositions containing a Mannich condensation product, a poly(oxyalkylene) monool, and a carboxylic acid | Chevron Oronite Company LLC (US) | 2003-07-02 | — | — | EP | disclosed |
| EP-0219035-A2 | Process for the preparation of polyamines, and their use in the preparation of polyurethanes | BAYER AG (DE) | 1987-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336721-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | MIF, MMP12, CSF1R | HSD17B10 1796/4885CYP3A4 2573/4885CYP2D6 3685/4885 |
| US-20080096887-A1 | cell proliferation, such as cancer, inflammation, and angiogenesis; fungal infections; antimalaria; Heat hock protein 90 (HSP-90) inhibitor | HSP90AA1, HSP90AB1, HSPA4 | HSD17B10 1430/4885CYP3A4 1143/4885CYP2D6 1950/4885 |
| US-20180179176-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | MIF, MMP12, CSF1R | HSD17B10 1796/4885CYP3A4 2573/4885CYP2D6 3685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.