Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 10/20 | 0.52 |
| ▸ | KCNJ5 | P48544 | 10/20 | 0.52 |
| ▸ | KCNJ3 | P48549 | 10/20 | 0.52 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392426 | 0.97 | KCNJ6 (0.50) | KCNJ6KCNJ5KCNJ3GBA1TNF | |
| SCHEMBL3391094 | 0.93 | KCNJ6 (0.47) | KCNJ6KCNJ5KCNJ3GBA1TNF | |
| SCHEMBL3390667 | 0.90 | KCNJ6 (0.45) | KCNJ6KCNJ5KCNJ3GBA1TNF | |
| SCHEMBL3394326 | 0.88 | KCNJ6 (0.47) | KCNJ6KCNJ5KCNJ3TNFMAPK14 | |
| SCHEMBL3390169 | 0.86 | MAPK14 (0.49) | TNFMAPK14BRAF | |
| SCHEMBL3392551 | 0.85 | KCNJ6 (0.42) | KCNJ6KCNJ5KCNJ3TNFMAPK14 | |
| SCHEMBL3392491 | 0.85 | KCNJ6 (0.48) | KCNJ6KCNJ5KCNJ3TNFMAPK14 | |
| SCHEMBL3392430 | 0.84 | KCNJ6 (0.39) | KCNJ6KCNJ5KCNJ3GBA1BRAF | |
| SCHEMBL3391154 | 0.84 | MAPK14 (0.47) | TNFMAPK14BRAF | |
| SCHEMBL3392130 | 0.83 | KCNJ6 (0.41) | KCNJ6KCNJ5KCNJ3TNFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |
| CN-101296922-A | Kinase inhibitors | LILLY CO ELI (US) | 2008-10-29 | — | — | CN | disclosed |