Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391154 | 0.97 | MAPK14 (0.47) | MAPK14TNFABL1PTK2BMAPK13 | |
| SCHEMBL27720462 | 0.91 | MAPK14 (0.51) | MAPK14TNFPTK2BMAPK13MAPK12 | |
| SCHEMBL3393220 | 0.89 | MAPK14 (0.52) | MAPK14PTK2BMAPK13MAPK12MAPK11 | |
| SCHEMBL3389724 | 0.89 | MAPK14 (0.49) | MAPK14TNFPTK2BMAPK13MAPK12 | |
| SCHEMBL3389950 | 0.86 | KCNJ6 (0.52) | MAPK14TNFBRAF | |
| SCHEMBL27720483 | 0.84 | MAPK14 (0.46) | MAPK14TNFPTK2BMAPK13MAPK12 | |
| SCHEMBL3392426 | 0.84 | KCNJ6 (0.50) | MAPK14TNFBRAF | |
| SCHEMBL3415918 | 0.84 | BRAF (0.47) | MAPK14TNFABL1PTK2BMAPK13 | |
| SCHEMBL3390975 | 0.83 | MAPK14 (0.52) | MAPK14TNFABL1PTK2BMAPK13 | |
| SCHEMBL3391158 | 0.83 | GBA1 (0.37) | MAPK14TNFBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |
| CN-101296922-A | Kinase inhibitors | LILLY CO ELI (US) | 2008-10-29 | — | — | CN | disclosed |