Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14370075 | 0.79 | KMT2A (0.59) | KMT2AMEN1ALDH1A1HPGDGAA | |
| SCHEMBL13007386 | 0.76 | ALDH1A1 (0.50) | KMT2AMEN1ALDH1A1HPGDGAA | |
| SCHEMBL4798275 | 0.76 | KMT2A (1.00) | KMT2AMEN1ALDH1A1HPGDGAA | |
| SCHEMBL4800601 | 0.74 | KMT2A (0.76) | KMT2AMEN1ALDH1A1HPGDGAA | |
| SCHEMBL13007428 | 0.72 | MEN1 (0.46) | KMT2AMEN1ALDH1A1HPGDGAA | |
| SCHEMBL11820042 | 0.69 | KMT2A (0.45) | KMT2AMEN1ALDH1A1HPGDGAA | |
| SCHEMBL15492070 | 0.68 | HPGD (0.48) | KMT2AMEN1ALDH1A1HPGDGAA | |
| SCHEMBL11081773 | 0.67 | MAPT (0.58) | KMT2AMEN1ALDH1A1GAALMNA | |
| SCHEMBL4831546 | 0.66 | KMT2A (0.62) | KMT2AMEN1ALDH1A1HPGDGAA | |
| SCHEMBL7654082 | 0.65 | MEN1 (0.56) | KMT2AMEN1L3MBTL1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423380-B1 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2010-12-15 | — | — | EP | disclosed |
| EP-1423380-B1 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2010-12-15 | — | — | EP | disclosed |
| EP-1423382-B1 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1423382-B1 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2008-04-16 | — | — | EP | disclosed |
| US-7279476-B2 | Anticancer agents, antiinflamamtory agents, restenosis, cardiovascular disorders; insertable device | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279476-B2 | Anticancer agents, antiinflamamtory agents, restenosis, cardiovascular disorders; insertable device | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279476-B2 | Anticancer agents, antiinflamamtory agents, restenosis, cardiovascular disorders; insertable device | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-09 | — | — | US | disclosed |
| US-7183307-B2 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCROPORATED (US) | 2007-02-27 | — | — | US | disclosed |
| US-7183307-B2 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCROPORATED (US) | 2007-02-27 | — | — | US | disclosed |
| US-7183307-B2 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCROPORATED (US) | 2007-02-27 | — | — | US | disclosed |
| US-20050215550-A1 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2005-09-29 | — | — | US | disclosed |
| US-6875789-B2 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-04-05 | — | — | US | disclosed |
| US-20040209935-A1 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-10-21 | — | — | US | disclosed |
| US-6750239-B2 | USEFUL FOR TREATING DISEASE STATES IN MAMMALS THAT ARE ALLEVIATED BY A PROTEIN KINASE INHIBITOR, PARTICULARLY DISEASES SUCH AS CANCER, INFLAMMATORY DISORDERS, RESTENOSIS, AND CARDIOVASCULAR DISEASE | VERTEX PHARMACEUTICALS INCORPORATED | 2004-06-15 | — | — | US | disclosed |
| EP-1423382-A2 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1423380-A1 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2004-06-02 | — | — | EP | disclosed |
| US-20030144337-A1 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2003-07-31 | — | — | US | disclosed |
| US-20030139452-A1 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2003-07-24 | — | — | US | disclosed |
| WO-2003011855-A2 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-02-13 | — | — | WO | disclosed |
| WO-2003011854-A1 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209935-A1 | Pyrazole-derived kinase inhibitors and uses thereof | RAF1, MAP3K1, MAP3K3 | KMT2A 2557/4885MEN1 3250/4885ALDH1A1 2903/4885 |
| US-20050215550-A1 | Pyrazole-derived kinase inhibitors and uses thereof | MAP3K19, MAP3K1, MAP3K3 | KMT2A 2406/4885MEN1 3220/4885ALDH1A1 3683/4885 |
| US-20030139452-A1 | Pyrazole-derived kinase inhibitors and uses thereof | RAF1, MAP3K1, MAP3K3 | KMT2A 2748/4885MEN1 3208/4885ALDH1A1 3191/4885 |
| US-20030144337-A1 | Pyrazole-derived kinase inhibitors and uses thereof | RAF1, MAP3K1, MAP3K3 | KMT2A 2557/4885MEN1 3250/4885ALDH1A1 2903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.