Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13945284 | 1.00 | KCNH2 (0.38) | KCNH2ADRB2KDM4EHPGDSTAT3 | |
| SCHEMBL3391639 | 0.92 | KCNH2 (0.44) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL13968307 | 0.81 | CYP2C19 (0.40) | KDM4EHPGDCYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL2670352 | 0.81 | KCNH2 (0.38) | KCNH2ADRB2KDM4EHPGDSTAT3 | |
| SCHEMBL3394346 | 0.81 | MEN1 (0.32) | KDM4EHPGDALDH1A1HSD17B10KMT2A | |
| SCHEMBL3389893 | 0.79 | KCNH2 (0.49) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL3391189 | 0.79 | KCNH2 (0.49) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL3389116 | 0.79 | KCNH2 (0.49) | KCNH2KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL12426651 | 0.79 | KCNH2 (0.39) | KCNH2KDM4EHPGDCYP2C19ALDH1A1 | |
| SCHEMBL8741054 | 0.76 | ADRB2 (0.51) | KCNH2ADRB2KDM4EHPGDSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1857453-B1 | FLUOROALKYLPYRROLIDINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2010-12-29 | — | — | EP | disclosed |
| EP-1857453-B1 | FLUOROALKYLPYRROLIDINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2010-12-29 | — | — | EP | disclosed |
| US-20090012119-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2009-01-08 | — | — | US | disclosed |
| US-20090012119-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2009-01-08 | — | — | US | disclosed |
| US-20090012119-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2009-01-08 | — | — | US | disclosed |
| EP-1857453-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2007-11-21 | — | — | EP | disclosed |
| EP-1857453-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012119-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | FPR1, VIP, Q6ZSR9 | KCNH2 139/4885ADRB2 1863/4885KDM4E 2389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.