Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 5/20 | 0.35 |
| ▸ | HRH1 | P35367 | 5/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17183751 | 1.00 | NR1I2 (0.44) | NR1I2SIGMAR1LMNACCR5HTR2A | |
| SCHEMBL27567790 | 1.00 | NR1I2 (0.44) | NR1I2SIGMAR1LMNACCR5HTR2A | |
| SCHEMBL11099949 | 1.00 | NR1I2 (0.44) | NR1I2SIGMAR1LMNACCR5HTR2A | |
| SCHEMBL17183686 | 1.00 | NR1I2 (0.44) | NR1I2SIGMAR1LMNACCR5HTR2A | |
| SCHEMBL9869713 | 0.98 | SIGMAR1 (0.42) | NR1I2SIGMAR1LMNACCR5HTR2A | |
| SCHEMBL3385362 | 0.92 | LMNA (0.42) | NR1I2SIGMAR1LMNACCR5HTR2A | |
| SCHEMBL8847425 | 0.88 | HRH1 (0.39) | SIGMAR1HTR2AHRH1TAAR1CYP2D6 | |
| SCHEMBL17183643 | 0.87 | SIGMAR1 (0.40) | NR1I2SIGMAR1LMNAHTR2AHRH1 | |
| SCHEMBL10597887 | 0.87 | NR1I2 (0.43) | NR1I2SIGMAR1HTR2ACYP19A1 | |
| SCHEMBL5933904 | 0.87 | NR1I2 (0.43) | NR1I2SIGMAR1HTR2ACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043633-A1 | 2H-PYRAZOLO [4,3-D]PYRIMIDIN-5-AMINE DERIVATIVES AS H4 HISTAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES | PALAU PHARMA, S. A. (ES) | 2010-04-22 | — | — | WO | disclosed |