Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392283 | 0.91 | EPHX2 (0.36) | EPHX2GRM2CHRM2CHRM1CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL3390721 | 0.83 | EPHX2 (0.36) | EPHX2GRM2CHRM2CHRM1CYP2C9 | |
| SCHEMBL3715589 | 0.82 | GRM2 (0.37) | EPHX2GRM2ADORA2BL3MBTL1 | |
| Hydrochloric Acid SCHEMBL3395503 | 0.81 | GRM2 (0.37) | EPHX2GRM2ADORA2BL3MBTL1 | |
| SCHEMBL3392702 | 0.77 | ACACB (0.34) | ADORA2BACACB | |
| Trifluoroacetic Acid SCHEMBL3392279 | 0.74 | EPHX2 (0.36) | EPHX2GRM2CYP2C9CYP2C19FFAR4 | |
| SCHEMBL3713843 | 0.73 | GRM2 (0.37) | EPHX2GRM2ADORA2BFAAH | |
| SCHEMBL3398158 | 0.73 | LSS (0.38) | GRM2 | |
| SCHEMBL3398119 | 0.68 | PRMT1 (0.46) | GRM2CYP2C9CYP2C19MCHR1 | |
| SCHEMBL13070089 | 0.68 | GRM2 (0.46) | EPHX2GRM2CHRM2CHRM1SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | claimed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |