Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 3/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398119 | 0.92 | PRMT1 (0.46) | LSSSERPINE1GRM2PTGER4PRMT1 | |
| SCHEMBL3395496 | 0.90 | HDAC3 (0.35) | LSSGRM2GNRHRPRMT1 | |
| SCHEMBL3392702 | 0.82 | ACACB (0.34) | LSS | |
| Trifluoroacetic Acid SCHEMBL3398157 | 0.77 | SERPINE1 (0.40) | LSSSERPINE1PRMT6GRM2PTGER4 | |
| SCHEMBL3712620 | 0.76 | SLC2A1 (0.41) | LSSSERPINE1PRMT6GRM2PRMT1 | |
| Hydrochloric Acid SCHEMBL3394437 | 0.75 | SLC2A1 (0.40) | LSSSERPINE1PRMT6GRM2PRMT1 | |
| SCHEMBL3713576 | 0.75 | SLC2A1 (0.42) | LSSSERPINE1PRMT6GRM2PRMT1 | |
| Hydrochloric Acid SCHEMBL3398480 | 0.74 | SLC2A1 (0.41) | LSSSERPINE1PRMT6GRM2PRMT1 | |
| SCHEMBL3390723 | 0.73 | EPHX2 (0.36) | GRM2 | |
| Trifluoroacetic Acid SCHEMBL3398116 | 0.71 | PRMT1 (0.47) | SERPINE1PTGER4PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | claimed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |