Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 4/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398158 | 0.92 | LSS (0.38) | PRMT1LSSGRM2PTGER4SERPINE1 | |
| SCHEMBL3395496 | 0.86 | HDAC3 (0.35) | PRMT1MCHR1LSSESR1GRM2 | |
| Trifluoroacetic Acid SCHEMBL3398116 | 0.81 | PRMT1 (0.47) | PRMT1SCN10AABCB1MCHR1ESR1 | |
| SCHEMBL3709650 | 0.81 | PRMT1 (0.51) | PRMT1SCN10AABCB1MCHR1ESR1 | |
| Hydrochloric Acid SCHEMBL3398629 | 0.80 | PRMT1 (0.52) | PRMT1SCN10AABCB1MCHR1ESR1 | |
| SCHEMBL3392702 | 0.77 | ACACB (0.34) | LSS | |
| SCHEMBL3392207 | 0.74 | PRMT1 (0.62) | PRMT1SCN10AABCB1ALDH1A1MAPT | |
| SCHEMBL3395850 | 0.73 | PRMT1 (0.59) | PRMT1SCN10AABCB1MCHR1LSS | |
| Trifluoroacetic Acid SCHEMBL3398157 | 0.70 | SERPINE1 (0.40) | LSSESR1GRM2PTGER4SERPINE1 | |
| SCHEMBL3713576 | 0.70 | SLC2A1 (0.42) | PRMT1LSSGRM2ALDH1A1SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | claimed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |