Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8157573 | 0.84 | AOC3 (0.48) | TAAR1AOC3HKDC1LMNASLC6A2 | |
| SCHEMBL7511093 | 0.83 | TAAR1 (0.59) | TAAR1AOC3HKDC1LMNARIPK1 | |
| SCHEMBL11130809 | 0.83 | HKDC1 (0.50) | TAAR1AOC3HKDC1LMNACHRM2 | |
| SCHEMBL7511084 | 0.83 | TAAR1 (0.59) | TAAR1AOC3HKDC1LMNARIPK1 | |
| SCHEMBL2464535 | 0.81 | TAAR1 (0.47) | TAAR1AOC3HKDC1LMNARIPK1 | |
| SCHEMBL10831187 | 0.81 | TAAR1 (0.47) | TAAR1AOC3HKDC1LMNARIPK1 | |
| SCHEMBL7043124 | 0.79 | TAAR1 (0.45) | TAAR1AOC3HKDC1LMNARIPK1 | |
| SCHEMBL22029995 | 0.79 | TAAR1 (0.45) | TAAR1AOC3HKDC1LMNARIPK1 | |
| SCHEMBL7043126 | 0.79 | AOC3 (0.50) | TAAR1AOC3HKDC1LMNARIPK1 | |
| SCHEMBL12803686 | 0.79 | TAAR1 (0.45) | TAAR1AOC3HKDC1LMNARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010094721-A1 | PIPERIDIN-PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF HISTAMINE H4 RECEPTOR | PALAU PHARMA, S. A. (ES) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010043633-A1 | 2H-PYRAZOLO [4,3-D]PYRIMIDIN-5-AMINE DERIVATIVES AS H4 HISTAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES | PALAU PHARMA, S. A. (ES) | 2010-04-22 | — | — | WO | disclosed |
| CN-1293061-C | Novel branched substituted amino derivatives of 3-amino-1-phenyl-1H- [1,2,4] triazole, process for their preparation and pharmaceutical compositions containing them | SANOFI SYNTHELABO (FR) | 2007-01-03 | — | — | CN | disclosed |
| CN-1434808-A | Novel branched substituted amino derivatives of 3-amino-1-phemyl-1H[1,2,4]triazo, methods for producing them and pharmaceutica compositions containing them | SANOFI SYNTHELABO (FR) | 2003-08-06 | — | — | CN | disclosed |