Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801455 | 0.83 | ALDH1A1 (0.40) | ALDH1A1MAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL31066375 | 0.82 | ALDH1A1 (0.42) | ALDH1A1MAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL29777591 | 0.81 | MAPK1 (0.40) | ALDH1A1MAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL31158416 | 0.80 | MAPK1 (0.42) | ALDH1A1MAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL3387081 | 0.79 | MAPT (0.40) | ALDH1A1MAPK1MAPTALOX15LMNA | |
| SCHEMBL3799255 | 0.79 | PDE3B (0.39) | ALDH1A1MAPK1KDM4EMAPTGAA | |
| SCHEMBL3798240 | 0.79 | PDE3B (0.39) | ALDH1A1MAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL6382734 | 0.77 | GAA (0.33) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL25985964 | 0.77 | MAPK1 (0.37) | ALDH1A1MAPK1KDM4EHSD17B10HPGD | |
| SCHEMBL6383258 | 0.76 | ALDH1A1 (0.35) | ALDH1A1MAPK1KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043633-A1 | 2H-PYRAZOLO [4,3-D]PYRIMIDIN-5-AMINE DERIVATIVES AS H4 HISTAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES | PALAU PHARMA, S. A. (ES) | 2010-04-22 | — | — | WO | disclosed |