Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29777591 | 0.85 | MAPK1 (0.40) | PDE3BPDE3AKDM4EGAAMAPK1 | |
| SCHEMBL3798240 | 0.83 | PDE3B (0.39) | PDE3BPDE3AKDM4EGAAMAPK1 | |
| SCHEMBL25434756 | 0.83 | KDM5B (0.36) | KDM4ENPC1RAB9AL3MBTL1NPBWR1 | |
| SCHEMBL30680379 | 0.82 | GABRG2 (0.35) | KDM4ENPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL25985964 | 0.81 | MAPK1 (0.37) | PDE3BPDE3AKDM4EGAAMAPK1 | |
| SCHEMBL25985965 | 0.80 | ALDH1A1 (0.41) | PDE3BPDE3AKDM4ENPC1RAB9A | |
| SCHEMBL3390958 | 0.79 | ALDH1A1 (0.48) | KDM4EL3MBTL1GAAMAPK1ALDH1A1 | |
| SCHEMBL3801455 | 0.79 | ALDH1A1 (0.40) | PDE3BPDE3AKDM4ENPC1RAB9A | |
| SCHEMBL31066375 | 0.78 | ALDH1A1 (0.42) | KDM4ENPC1RAB9AL3MBTL1GAA | |
| SCHEMBL26687047 | 0.77 | ADORA1 (0.42) | KDM4EGAAALDH1A1POLBGABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010117425-A1 | CERTAIN SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | BIOGEN IDEC MA INC. (US) | 2010-10-14 | — | — | WO | disclosed |