Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM6B | O15054 | 1/20 | 0.52 |
| ▸ | TET3 | O43151 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 1/20 | 0.52 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | KDM5C | P41229 | 1/20 | 0.52 |
| ▸ | ASPH | Q12797 | 1/20 | 0.52 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.52 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.52 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.52 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.52 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.52 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7513922 | 0.84 | KMO (0.71) | KMOKDM4EALDH1A1MAPTKDM6B | |
| SCHEMBL30800092 | 0.84 | KMO (0.71) | KMOKDM4EALDH1A1MAPTKDM6B | |
| SCHEMBL8337311 | 0.78 | NPC1 (0.52) | HDAC1HDAC6NPC1RAB9AKMT2A | |
| SCHEMBL28284992 | 0.78 | KDM4E (0.66) | KMOKDM4EALDH1A1MAPTKDM6B | |
| SCHEMBL2558040 | 0.77 | KMO (0.58) | KMOKDM4EALDH1A1MAPTKDM6B | |
| SCHEMBL16673126 | 0.77 | KMO (0.62) | KMOKDM4EALDH1A1MAPTKDM6B | |
| SCHEMBL725162 | 0.77 | KMO (0.62) | KMOKDM4EALDH1A1MAPTKDM6B | |
| SCHEMBL24572141 | 0.76 | KMO (0.62) | KMOKDM4EALDH1A1MAPTKDM6B | |
| SCHEMBL3223512 | 0.76 | KMO (0.62) | KMOKDM4EALDH1A1MAPTKDM6B | |
| SCHEMBL25174367 | 0.76 | KMO (0.72) | KMOKDM4EALDH1A1MAPTKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |