Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 4/20 | 0.38 |
| ▸ | ACACB | O00763 | 14/20 | 0.37 |
| ▸ | ACACA | Q13085 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17435093 | 0.93 | ACACB (0.39) | CXCR2ACACBACACAPOLBCXCR1 | |
| SCHEMBL3362077 | 0.84 | ACACB (0.37) | ACACBACACA | |
| SCHEMBL3363978 | 0.84 | PTK2 (0.43) | ACACBACACA | |
| SCHEMBL17435099 | 0.80 | CYP1A2 (0.48) | POLB | |
| SCHEMBL3363976 | 0.76 | PTK2 (0.46) | ACACB | |
| SCHEMBL3362074 | 0.76 | ACACB (0.39) | ACACBACACAPOLB | |
| SCHEMBL12985792 | 0.74 | ALDH1A1 (0.39) | CXCR2CXCR1 | |
| SCHEMBL15174163 | 0.70 | ALDH1A1 (0.39) | CXCR2CXCR1 | |
| SCHEMBL2499613 | 0.70 | ACACB (0.34) | ACACB | |
| SCHEMBL24328889 | 0.66 | APLNR (0.44) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373317-B1 | 4-amino-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one or 4-amino-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one derivatives as activators of the soluble guanylat cyclase for the treatment of cardiovascular diseases | MERCK SHARP & DOHME (US) | 2016-12-14 | — | — | EP | disclosed |
| EP-2575473-B1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2575473-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | Merck Sharp & Dohme Corp. (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011149921-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2010065275-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2010-06-10 | — | — | WO | disclosed |