Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3988315 | 0.85 | TLR9 (0.40) | GPR119RETCNR1KDM4EMAPT | |
| SCHEMBL3395456 | 0.85 | KDM4E (0.43) | HTTGPR119RETCNR1KDM4E | |
| SCHEMBL3392944 | 0.85 | HTT (0.47) | HPGDSHTTGPR119USP30KDM4E | |
| SCHEMBL4665016 | 0.78 | HTT (0.48) | HPGDSHTTGPR119CNR1KDM4E | |
| SCHEMBL3395565 | 0.76 | GPR119 (0.49) | HPGDSHTTGPR119CNR1KDM4E | |
| SCHEMBL3395346 | 0.76 | JAK2 (0.45) | HPGDSHTTGPR119JAK2 | |
| SCHEMBL14737550 | 0.75 | JAK2 (0.52) | HPGDSHTTGPR119CNR1KDM4E | |
| SCHEMBL29468210 | 0.75 | JAK2 (0.52) | HPGDSHTTGPR119CNR1KDM4E | |
| SCHEMBL3391151 | 0.75 | GPR119 (0.48) | HTTGPR119CNR1KDM4EMAPT | |
| SCHEMBL3395713 | 0.74 | PTPN2 (0.48) | HTTGPR119USP30KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501780-B2 | Indazole carboxamides and their use | GLAXOSMITHKLINE LLC (US) | 2013-08-06 | — | — | US | disclosed |
| US-8501780-B2 | Indazole carboxamides and their use | GLAXOSMITHKLINE LLC (US) | 2013-08-06 | — | — | US | disclosed |
| US-8501780-B2 | Indazole carboxamides and their use | GLAXOSMITHKLINE LLC (US) | 2013-08-06 | — | — | US | disclosed |
| EP-1758578-B1 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | GLAXOSMITHKLINE LLC (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-1758578-B1 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | GLAXOSMITHKLINE LLC (US) | 2010-12-29 | — | — | EP | disclosed |
| US-20070281933-A1 | Novel Indazole Carboxamides And Their Use | SMITHKLINE BEECHAM CORPORATION (US) | 2007-12-06 | — | — | US | disclosed |
| US-20070281933-A1 | Novel Indazole Carboxamides And Their Use | SMITHKLINE BEECHAM CORPORATION (US) | 2007-12-06 | — | — | US | disclosed |
| US-20070281933-A1 | Novel Indazole Carboxamides And Their Use | SMITHKLINE BEECHAM CORPORATION (US) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281933-A1 | Novel Indazole Carboxamides And Their Use | IKBKG, IRAK2, NFKBIA | HPGDS 2264/4885HTT 4472/4885GPR119 1335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.