Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12940365 | 0.96 | ALOX5 (0.46) | PTGS2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL12940204 | 0.88 | PTGS2 (0.55) | PTGS2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL2299840 | 0.88 | MEN1 (0.56) | PTGS2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4790812 | 0.86 | PTGS2 (0.52) | PTGS2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL12940361 | 0.84 | ALOX5 (0.51) | PTGS2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL2298170 | 0.84 | PTGS2 (0.50) | PTGS2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL2297483 | 0.84 | PTGS2 (0.50) | PTGS2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL6119870 | 0.83 | ALOX5 (0.50) | PTGS2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4792819 | 0.83 | ALOX5 (0.45) | PTGS2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL1918070 | 0.82 | MEN1 (0.56) | PTGS2MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245023-B1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2011-12-28 | — | — | EP | disclosed |
| EP-2245023-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009101022-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-20 | — | — | WO | disclosed |