Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.45 |
| ▸ | BTK | Q06187 | 5/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3393401 | 0.80 | PIK3CA (0.42) | SYKJAK2EGFR | |
| SCHEMBL1048925 | 0.79 | ZAP70 (0.52) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL3394237 | 0.79 | DYRK1A (0.36) | SYKBTKJAK2PDGFRBPDGFRA | |
| SCHEMBL3391477 | 0.78 | SYK (0.38) | SYKBTKPDGFRBPDGFRA | |
| SCHEMBL3390916 | 0.72 | ROCK2 (0.41) | — | |
| SCHEMBL3363319 | 0.72 | SYK (0.44) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL3362139 | 0.71 | SYK (0.48) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL3392852 | 0.71 | SYK (0.38) | SYK | |
| SCHEMBL3359732 | 0.71 | SYK (0.45) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL27826732 | 0.70 | RET (0.43) | SYKPDGFRBPDGFRAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |