Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.38 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391477 | 0.93 | SYK (0.38) | SYKTRPV1 | |
| SCHEMBL1047845 | 0.76 | ZAP70 (0.48) | SYKMKNK1ROCK1 | |
| SCHEMBL3390916 | 0.73 | ROCK2 (0.41) | ROCK2ROCK1 | |
| SCHEMBL3393401 | 0.71 | PIK3CA (0.42) | SYKROCK2ROCK1 | |
| SCHEMBL3391527 | 0.71 | SYK (0.45) | SYK | |
| SCHEMBL1044891 | 0.69 | ZAP70 (0.48) | SYKROCK2ROCK1 | |
| SCHEMBL3392219 | 0.69 | CDK5 (0.41) | SYK | |
| SCHEMBL3362139 | 0.68 | SYK (0.48) | SYK | |
| SCHEMBL27826732 | 0.68 | RET (0.43) | SYK | |
| SCHEMBL3394237 | 0.66 | DYRK1A (0.36) | SYKROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |