Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392335 | 0.80 | PTGDR2 (0.36) | HPGDTSHRNPC1RAB9AMCHR1 | |
| SCHEMBL4986188 | 0.75 | HPGD (0.55) | HPGDTSHRNPC1RAB9AATM | |
| SCHEMBL9001770 | 0.74 | SLC6A4 (0.59) | HPGDTSHRNPC1RAB9APOLB | |
| SCHEMBL27661269 | 0.73 | HPGD (0.46) | HPGDTSHRNPC1RAB9AATM | |
| SCHEMBL9001760 | 0.71 | TSHR (0.79) | HPGDTSHRNPC1RAB9AATM | |
| SCHEMBL4359670 | 0.71 | HPGD (0.59) | HPGDTSHRNPC1RAB9AATM | |
| SCHEMBL3388956 | 0.70 | KMT2A (0.54) | HPGDNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL293511 | 0.70 | ALDH1A1 (0.38) | HPGDNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL1001922 | 0.69 | HPGD (0.62) | HPGDTSHRNPC1RAB9AATM | |
| SCHEMBL14374144 | 0.69 | HPGD (0.62) | HPGDTSHRNPC1RAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | claimed |
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |