Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 4/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 3/20 | 0.31 |
| ▸ | DRD3 | P35462 | 3/20 | 0.31 |
| ▸ | DRD1 | P21728 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391597 | 0.80 | HPGD (0.48) | NPC1RAB9AMCHR1HPGDTSHR | |
| SCHEMBL3388956 | 0.66 | KMT2A (0.54) | NPC1RAB9AHPGD | |
| SCHEMBL3899987 | 0.64 | IDO1 (0.42) | HPGDTSHR | |
| SCHEMBL1583641 | 0.63 | DRD2 (0.34) | NPC1RAB9AMCHR1SLC6A4DRD4 | |
| SCHEMBL293511 | 0.63 | ALDH1A1 (0.38) | NPC1RAB9AHPGD | |
| SCHEMBL28244770 | 0.62 | HTR1A (0.45) | NPC1RAB9ASLC6A4DRD4HTR1A | |
| SCHEMBL22101911 | 0.62 | SLC6A4 (0.34) | PTGDR2MCHR1SLC6A4 | |
| SCHEMBL1583274 | 0.62 | DRD2 (0.36) | NPC1RAB9ASLC6A4DRD4DRD2 | |
| SCHEMBL3868805 | 0.62 | SLC6A4 (0.56) | PTGDR2NPC1RAB9AMCHR1KCNH2 | |
| SCHEMBL5748265 | 0.61 | KDM4E (0.44) | HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | claimed |
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |