Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.63 |
| ▸ | CA1 | P00915 | 3/20 | 0.59 |
| ▸ | CA2 | P00918 | 3/20 | 0.59 |
| ▸ | ACHE | P22303 | 3/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | TAOK3 | Q9H2K8 | 4/20 | 0.51 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5526850 | 0.96 | MTNR1A (0.68) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL6523015 | 0.96 | MTNR1A (0.68) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL3395108 | 0.93 | CA1 (0.64) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL2079654 | 0.89 | KMT2A (0.56) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL5522805 | 0.86 | MTNR1A (0.60) | MTNR1AMTNR1BTAOK3TAOK1KMT2A | |
| SCHEMBL3392060 | 0.86 | MTNR1A (0.60) | MTNR1AMTNR1BTAOK3TAOK1KMT2A | |
| SCHEMBL3390898 | 0.86 | MTNR1A (0.60) | MTNR1AMTNR1BTAOK3TAOK1KMT2A | |
| SCHEMBL6513612 | 0.80 | MTNR1A (0.70) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL10253556 | 0.80 | MTNR1A (0.61) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL6513609 | 0.80 | MTNR1A (0.70) | MTNR1AMTNR1BCA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370530-B1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-12-29 | — | — | EP | disclosed |
| EP-1370530-A1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | Aventis Pharma Deutschland GmbH (DE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002064565-A1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-08-22 | — | — | WO | disclosed |