Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | TAOK3 | Q9H2K8 | 4/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | CTSC | P53634 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5522805 | 1.00 | MTNR1A (0.60) | MTNR1AMTNR1BNPC1RAB9ATAOK1 | |
| SCHEMBL3392060 | 1.00 | MTNR1A (0.60) | MTNR1AMTNR1BNPC1RAB9ATAOK1 | |
| SCHEMBL3796486 | 0.92 | NPC1 (0.62) | MTNR1AMTNR1BNPC1RAB9ASLC6A12 | |
| SCHEMBL248645 | 0.90 | NPC1 (0.61) | NPC1RAB9ASLC6A12TMEM97MCHR1 | |
| SCHEMBL9731843 | 0.88 | MTNR1A (0.67) | MTNR1AMTNR1BNPC1RAB9ATAOK1 | |
| SCHEMBL3391773 | 0.86 | MTNR1A (0.63) | MTNR1AMTNR1BTAOK1HDAC8HDAC6 | |
| SCHEMBL30823644 | 0.86 | MEN1 (0.68) | MTNR1AMTNR1BNPC1RAB9ATAOK1 | |
| SCHEMBL22289338 | 0.86 | MEN1 (0.68) | MTNR1AMTNR1BNPC1RAB9ATAOK1 | |
| SCHEMBL3393940 | 0.83 | MTNR1A (0.60) | MTNR1AMTNR1BNPC1RAB9ATAOK1 | |
| SCHEMBL3393202 | 0.83 | MTNR1A (0.60) | MTNR1AMTNR1BNPC1RAB9ATAOK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241811-B2 | E.g., 1-(pyridin-4-ylcarbamoyl)-1,2,3,6- tetrahydropyridine hydrochloride; therapy and prophylaxis of amnesia or dementia | ASTELLAS PHARMA INC. (JP) | 2007-07-10 | — | — | US | claimed |
| EP-1159258-B1 | AMIDE COMPOUNDS FOR THE POTENTIATION OF CHOLINERGIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-11-10 | — | — | EP | claimed |
| EP-1370530-B1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-12-29 | — | — | EP | disclosed |
| US-7241811-B2 | E.g., 1-(pyridin-4-ylcarbamoyl)-1,2,3,6- tetrahydropyridine hydrochloride; therapy and prophylaxis of amnesia or dementia | ASTELLAS PHARMA INC. (JP) | 2007-07-10 | — | — | US | disclosed |
| US-7037942-B2 | Amide compounds for the potentiation of cholinergic activity | ASTELLAS PHARMA INC. (JP) | 2006-05-02 | — | — | US | disclosed |
| US-20060058396-A1 | Amide compounds for the potentiation of cholinergic activity | ASTELLAS PHARMA INC. (JP) | 2006-03-16 | — | — | US | disclosed |
| US-6949556-B2 | Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-09-27 | — | — | US | disclosed |
| EP-1159258-B1 | AMIDE COMPOUNDS FOR THE POTENTIATION OF CHOLINERGIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-11-10 | — | — | EP | disclosed |
| US-20040048904-A1 | Amide compounds for the potentiation of cholinergic activity | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1370530-A1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | Aventis Pharma Deutschland GmbH (DE) | 2003-12-17 | — | — | EP | disclosed |
| US-6664293-B2 | For treatment and/or prevention of disorders in the central nervous system, particularly amnesia, dementia, Alzheimer's dementia | FUJIWAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| US-20030096847-A1 | Amide compounds for the potentiation of cholinergic activity | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2003-05-22 | — | — | US | disclosed |
| US-20030022935-A1 | Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2003-01-30 | — | — | US | disclosed |
| WO-2002064565-A1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-08-22 | — | — | WO | disclosed |
| EP-1159258-A1 | AMIDE COMPOUNDS FOR THE POTENTIATION OF CHOLINERGIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000051970-A1 | AMIDE COMPOUNDS FOR THE POTENTIATION OF CHOLINERGIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048904-A1 | Amide compounds for the potentiation of cholinergic activity | CHAT, CHRM2, CHRNA2 | MTNR1A 280/4885MTNR1B 333/4885NPC1 1538/4885 |
| US-20030022935-A1 | Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents | VEGFA, EDNRA, NR1H2 | MTNR1A 604/4885MTNR1B 448/4885NPC1 425/4885 |
| US-20060058396-A1 | Amide compounds for the potentiation of cholinergic activity | CHRM2, CHRM1, CHAT | MTNR1A 253/4885MTNR1B 287/4885NPC1 1479/4885 |
| US-20030096847-A1 | Amide compounds for the potentiation of cholinergic activity | CHAT, CHRM2, CHRNA2 | MTNR1A 280/4885MTNR1B 333/4885NPC1 1538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.