Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | HTR2B | P41595 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476953 | 0.75 | ANPEP (0.32) | MEN1KMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL3389204 | 0.70 | HTR2A (0.35) | HTR2AHTR2CANPEP | |
| SCHEMBL3634708 | 0.69 | PRCP (0.38) | MEN1KMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL4290508 | 0.68 | HTR2A (0.35) | HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL874497 | 0.68 | HTR2A (0.34) | HTR2AHTR2CCYP2C19ANPEP | |
| SCHEMBL458495 | 0.68 | HTR2A (0.35) | HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL455932 | 0.68 | HTR2A (0.34) | HTR2AHTR2CANPEP | |
| SCHEMBL6521360 | 0.68 | HTR2A (0.35) | HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL458123 | 0.68 | HTR2A (0.34) | HTR2AHTR2CANPEP | |
| SCHEMBL4307808 | 0.68 | HTR2A (0.34) | HTR2AHTR2CANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164329-A2 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | The Burnham Institute for Medical Research (US) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009136965-A1 | COMPOSITIONS AND METHODS COMPRISING CAPURAMYCIN ANALOGUES | SEQUELLA, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009017863-A2 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-02-05 | — | — | WO | disclosed |