Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.45 |
| ▸ | LOX | P28300 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30626327 | 0.84 | LOX (0.55) | AAK1FAAHDYRK1ALOXLOXL2 | |
| SCHEMBL16116782 | 0.84 | LOX (0.55) | AAK1FAAHDYRK1ALOXLOXL2 | |
| SCHEMBL13036116 | 0.79 | DYRK1A (0.55) | AAK1FAAHDYRK1ALOXLOXL2 | |
| SCHEMBL8337311 | 0.78 | NPC1 (0.52) | DYRK1A | |
| SCHEMBL28950139 | 0.78 | DYRK1A (0.61) | DYRK1A | |
| SCHEMBL29141734 | 0.77 | DYRK1A (0.53) | AAK1DYRK1ALOXLOXL2LRRK2 | |
| SCHEMBL729005 | 0.77 | PIK3CA (0.65) | AAK1DYRK1AIRAK4CLK1 | |
| SCHEMBL30042175 | 0.76 | CYP2A6 (0.57) | AAK1DYRK1ALOXLOXL2ACVR2A | |
| SCHEMBL22283952 | 0.76 | HSD17B1 (0.49) | AAK1FAAHDYRK1ALOXLOXL2 | |
| SCHEMBL20864258 | 0.76 | SLC13A5 (0.54) | AAK1FAAHDYRK1ALOXLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |