Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27668978 | 0.87 | MGLL (0.67) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL8291195 | 0.83 | MGLL (0.59) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL27668873 | 0.80 | MGLL (0.79) | MGLLNPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL3391599 | 0.80 | MGLL (0.62) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL10197956 | 0.79 | MGLL (0.56) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL10197837 | 0.77 | NPC1 (0.69) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL8291194 | 0.77 | MGLL (0.55) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL15290587 | 0.77 | MGLL (0.54) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL410155 | 0.75 | CMA1 (0.57) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL23086093 | 0.74 | MGLL (1.00) | MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |