Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27668873 | 0.82 | MGLL (0.79) | MGLLNPC1RAB9APTPN2PTPN1 | |
| SCHEMBL10197837 | 0.80 | NPC1 (0.69) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL3391972 | 0.80 | MGLL (0.59) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL27668978 | 0.79 | MGLL (0.67) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL23086100 | 0.77 | MGLL (0.77) | MGLLNPC1RAB9APTPN2PTPN1 | |
| SCHEMBL23086093 | 0.77 | MGLL (1.00) | MGLL | |
| SCHEMBL7302754 | 0.77 | NPC1 (0.72) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL8291195 | 0.75 | MGLL (0.59) | MGLLNPC1RAB9ACAPN1CTSB | |
| SCHEMBL4310722 | 0.73 | TSHR (0.84) | NPC1RAB9ADRD4TSHRHPGD | |
| SCHEMBL10282916 | 0.73 | NPC1 (0.74) | MGLLNPC1RAB9ACAPN1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | claimed |
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |