Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 18/20 | 0.43 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391937 | 1.00 | HSD11B1 (0.43) | HSD11B1HSD11B2ALDH1A1CRHBPHTT | |
| SCHEMBL975066 | 0.82 | HSD11B1 (0.44) | HSD11B1HSD11B2ALDH1A1CRHBPHTT | |
| SCHEMBL975067 | 0.82 | HSD11B1 (0.44) | HSD11B1HSD11B2ALDH1A1CRHBPHTT | |
| SCHEMBL3661870 | 0.82 | HSD11B1 (0.44) | HSD11B1HSD11B2ALDH1A1CRHBPHTT | |
| SCHEMBL12093270 | 0.82 | HSD11B1 (0.44) | HSD11B1HSD11B2ALDH1A1CRHBPHTT | |
| SCHEMBL975068 | 0.82 | HSD11B1 (0.44) | HSD11B1HSD11B2ALDH1A1CRHBPHTT | |
| SCHEMBL176523 | 0.80 | ALDH1A1 (0.52) | HSD11B1ALDH1A1CRHBPHTTCRHR2 | |
| SCHEMBL6877661 | 0.80 | ALDH1A1 (0.52) | HSD11B1ALDH1A1CRHBPHTTCRHR2 | |
| Hydrochloric Acid SCHEMBL976495 | 0.80 | HSD11B1 (0.43) | HSD11B1HSD11B2ALDH1A1CRHBPHTT | |
| Hydrochloric Acid SCHEMBL974232 | 0.80 | HSD11B1 (0.43) | HSD11B1HSD11B2ALDH1A1CRHBPHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364311-B1 | TROPANE UREA DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS MODULATORS OF THE ACTIVITY OF 11BETAHSD1 | SANOFI SA (FR) | 2013-07-03 | — | — | EP | disclosed |
| WO-2010049635-A1 | TROPANE UREA DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS MODULATORS OF THE ACTIVITY OF 11BETAHSD1 | SANOFI-AVENTIS (FR) | 2010-05-06 | — | — | WO | disclosed |