Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392307 | 1.00 | CCR5 (0.52) | CCR5LMNAALDH1A1OPRL1KMT2A | |
| Hydrochloric Acid SCHEMBL3388624 | 0.99 | CCR5 (0.51) | CCR5LMNAALDH1A1OPRL1KMT2A | |
| Hydrochloric Acid SCHEMBL3388619 | 0.99 | CCR5 (0.51) | CCR5LMNAALDH1A1OPRL1KMT2A | |
| SCHEMBL3391719 | 0.90 | CCR5 (0.53) | CCR5LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL3391721 | 0.90 | CCR5 (0.53) | CCR5LMNAALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL3389663 | 0.89 | CCR5 (0.52) | CCR5LMNAALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL3389664 | 0.89 | CCR5 (0.52) | CCR5LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL3391678 | 0.83 | CCR5 (0.47) | CCR5LMNAALDH1A1OPRL1KMT2A | |
| SCHEMBL3391680 | 0.83 | CCR5 (0.47) | CCR5LMNAALDH1A1OPRL1KMT2A | |
| SCHEMBL3387190 | 0.82 | OPRL1 (0.56) | CCR5OPRL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709642-B2 | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA, INC. (CA) | 2010-05-04 | — | — | US | claimed |