Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 9/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391721 | 1.00 | CCR5 (0.53) | CCR5KDM1AMAOBKMT2ASLC6A9 | |
| Hydrochloric Acid SCHEMBL3389663 | 0.99 | CCR5 (0.52) | CCR5KDM1AMAOBKMT2ASLC6A9 | |
| Hydrochloric Acid SCHEMBL3389664 | 0.99 | CCR5 (0.52) | CCR5KDM1AMAOBKMT2ASLC6A9 | |
| SCHEMBL3392304 | 0.90 | CCR5 (0.52) | CCR5KMT2AALDH1A1MEN1MAPK1 | |
| SCHEMBL3392307 | 0.90 | CCR5 (0.52) | CCR5KMT2AALDH1A1MEN1MAPK1 | |
| Hydrochloric Acid SCHEMBL3388619 | 0.90 | CCR5 (0.51) | CCR5KMT2AALDH1A1MEN1MAPK1 | |
| Hydrochloric Acid SCHEMBL3388624 | 0.90 | CCR5 (0.51) | CCR5KMT2AALDH1A1MEN1MAPK1 | |
| SCHEMBL3391408 | 0.85 | CCR5 (0.46) | CCR5KDM1AMAOBKMT2AALDH1A1 | |
| SCHEMBL3391406 | 0.85 | CCR5 (0.46) | CCR5KDM1AMAOBKMT2AALDH1A1 | |
| SCHEMBL3391693 | 0.85 | CCR5 (0.50) | CCR5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709642-B2 | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA, INC. (CA) | 2010-05-04 | — | — | US | claimed |