Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.34 |
| ▸ | DRD3 | P35462 | 6/20 | 0.34 |
| ▸ | DRD4 | P21917 | 4/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | BRD2 | P25440 | 2/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390894 | 0.81 | MAPT (0.36) | MAPTDRD2DRD3DRD4TSHR | |
| SCHEMBL3389944 | 0.81 | DRD2 (0.46) | MAPTDRD2DRD3DRD4HTR1D | |
| SCHEMBL6620561 | 0.78 | MAPT (0.34) | MAPTDRD2DRD3DRD4 | |
| SCHEMBL3390892 | 0.74 | DRD2 (0.40) | MAPTDRD2DRD3DRD4SMN1; SMN2 | |
| SCHEMBL6593135 | 0.73 | DRD2 (0.42) | DRD2DRD3DRD4HTR1D | |
| SCHEMBL6590352 | 0.70 | DRD3 (0.42) | MAPTDRD2DRD3DRD4HTR1D | |
| SCHEMBL3387755 | 0.70 | DRD2 (0.43) | MAPTDRD2DRD3DRD4 | |
| SCHEMBL5222458 | 0.69 | MAPT (0.37) | MAPTDRD2DRD3DRD4TSHR | |
| SCHEMBL6788728 | 0.68 | DRD2 (0.41) | MAPTDRD2DRD3DRD4 | |
| SCHEMBL3388370 | 0.68 | DRD2 (0.41) | DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453805-B1 | 4-PIPERIDINYL ALKYLAMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-12-22 | — | — | EP | disclosed |