Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392548 | 0.86 | MAPK14 (0.44) | MAPK14MAPK12MAPK13MAPK11BRAF | |
| SCHEMBL3178035 | 0.84 | MAPK14 (0.46) | MAPK14MAPK12MAPK13MAPK11BRAF | |
| SCHEMBL4481650 | 0.79 | MAPK14 (0.37) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3394279 | 0.79 | MALT1 (0.37) | MAPK14MAPK12MAPK13MAPK11GPR119 | |
| SCHEMBL3180417 | 0.76 | MAPK14 (0.37) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3394275 | 0.76 | MAPK14 (0.49) | MAPK14MAPK12MAPK13MAPK11BRAF | |
| SCHEMBL3392522 | 0.76 | MAPK14 (0.36) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL3170675 | 0.74 | NPY2R (0.35) | MAPK14MAPK12MAPK13MAPK11CACNA1B | |
| SCHEMBL3388916 | 0.74 | MAPK14 (0.38) | MAPK14MAPK12MAPK13MAPK11PTK2B | |
| SCHEMBL13528639 | 0.74 | MAPK14 (0.51) | MAPK14MAPK12MAPK13MAPK11DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |