Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 9/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
| ▸ | BCL9 | O00512 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3396252 | 1.00 | JAK3 (0.38) | JAK3IRAK1IRAK4LRRK2SYK | |
| SCHEMBL3393312 | 0.92 | PIM1 (0.41) | JAK3IRAK4SYKPIM1CARM1 | |
| SCHEMBL3396503 | 0.90 | JAK3 (0.39) | JAK3IRAK1IRAK4LRRK2MAPK1 | |
| SCHEMBL3397161 | 0.89 | JAK3 (0.38) | JAK3LRRK2MAPK1CARM1PRMT6 | |
| SCHEMBL3398973 | 0.89 | JAK3 (0.40) | JAK3IRAK4LRRK2MAPK1ATR | |
| SCHEMBL3396539 | 0.87 | JAK3 (0.36) | JAK3LRRK2MAPK1CARM1PRMT6 | |
| SCHEMBL3393905 | 0.87 | MCHR1 (0.37) | JAK3ATR | |
| SCHEMBL3395609 | 0.87 | PRKCA (0.41) | JAK3MAPK1ATRPRKCIPIM1 | |
| SCHEMBL3397048 | 0.87 | JAK3 (0.39) | JAK3SYKMAPK1ATRPRKCI | |
| SCHEMBL3399453 | 0.86 | JAK3 (0.36) | JAK3LRRK2MAPK1CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |