Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 5/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3393932 | 0.93 | JAK3 (0.36) | JAK3MAP4K1LRRK2MAPK1 | |
| SCHEMBL3397161 | 0.89 | JAK3 (0.38) | JAK3MAP4K1LRRK2CARM1PRMT6 | |
| SCHEMBL3396503 | 0.89 | JAK3 (0.39) | JAK3LRRK2CARM1PRMT6PRMT8 | |
| SCHEMBL3398973 | 0.88 | JAK3 (0.40) | JAK3MAP4K1CDC7LRRK2CARM1 | |
| SCHEMBL3394004 | 0.87 | JAK3 (0.38) | JAK3LRRK2CARM1PRMT6PRMT8 | |
| SCHEMBL3396252 | 0.87 | JAK3 (0.38) | JAK3LRRK2CARM1PRMT6PRMT8 | |
| SCHEMBL3393905 | 0.87 | MCHR1 (0.37) | JAK3 | |
| SCHEMBL3393312 | 0.87 | PIM1 (0.41) | JAK3CARM1PRMT6PRMT8 | |
| SCHEMBL3395609 | 0.87 | PRKCA (0.41) | JAK3MAP4K1CARM1PRMT6PRMT8 | |
| SCHEMBL3399453 | 0.86 | JAK3 (0.36) | JAK3MAP4K1LRRK2CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |
| EP-2247592-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106442-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |