Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | MLNR | O43193 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 6/20 | 0.35 |
| ▸ | DRD4 | P21917 | 6/20 | 0.35 |
| ▸ | DRD3 | P35462 | 6/20 | 0.35 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3397317 | 0.87 | HRH3 (0.41) | JAK3DRD2DRD4DRD3MGAT2 | |
| SCHEMBL13070030 | 0.84 | GRM2 (0.41) | JAK3JAK2JAK1GRM2STAT3 | |
| SCHEMBL3396963 | 0.84 | MAP3K11 (0.38) | JAK3MLNRJAK2JAK1DRD2 | |
| Hydrochloric Acid SCHEMBL3396770 | 0.83 | GRM2 (0.40) | JAK3JAK2JAK1GRM2STAT3 | |
| SCHEMBL3394837 | 0.82 | GRIN2B (0.40) | SLC2A1 | |
| SCHEMBL13070352 | 0.81 | SLC2A1 (0.41) | DRD2DRD3SLC2A1HRH3 | |
| Hydrochloric Acid SCHEMBL3394567 | 0.80 | SLC2A1 (0.40) | DRD2DRD3SLC2A1HRH3 | |
| SCHEMBL3394483 | 0.79 | TNKS (0.37) | JAK3GRM2DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL3394864 | 0.78 | MGAT2 (0.43) | DRD2DRD4DRD3MGAT2HRH3 | |
| SCHEMBL3710727 | 0.78 | HRH3 (0.46) | DRD2DRD4DRD3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | claimed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |