Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 6/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | DRD4 | P21917 | 4/20 | 0.33 |
| ▸ | DRD3 | P35462 | 4/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3397317 | 0.85 | HRH3 (0.41) | TNKSPARP1JAK3MGAT2DRD2 | |
| SCHEMBL3396969 | 0.84 | MAP3K11 (0.39) | TNKSPARP1GRM2HRH3MAP3K11 | |
| Hydrochloric Acid SCHEMBL3396774 | 0.84 | GRM2 (0.40) | GRM2JAK3DRD2DRD4DRD3 | |
| SCHEMBL3394839 | 0.80 | SPR (0.32) | DRD2DRD3 | |
| SCHEMBL3394476 | 0.79 | JAK3 (0.36) | GRM2JAK3MGAT2DRD2DRD4 | |
| SCHEMBL4565035 | 0.78 | TNKS (0.39) | TNKSPARP1 | |
| Hydrochloric Acid SCHEMBL3394572 | 0.78 | DRD3 (0.33) | DRD2DRD3 | |
| SCHEMBL3392240 | 0.77 | PRKAB2 (0.36) | CHEK1 | |
| SCHEMBL4475367 | 0.77 | ADORA2A (0.39) | — | |
| SCHEMBL4478743 | 0.77 | SLC2A1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | claimed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |