Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.63 |
| ▸ | KLK8 | O60259 | 4/20 | 0.63 |
| ▸ | KLK4 | Q9Y5K2 | 4/20 | 0.63 |
| ▸ | KLK2 | P20151 | 3/20 | 0.63 |
| ▸ | F2 | P00734 | 7/20 | 0.50 |
| ▸ | PLG | P00747 | 4/20 | 0.50 |
| ▸ | PLAT | P00750 | 3/20 | 0.50 |
| ▸ | F10 | P00742 | 4/20 | 0.48 |
| ▸ | KLK1 | P06870 | 1/20 | 0.48 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.45 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.45 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | C1S | P09871 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL563232 | 0.80 | KLK8 (0.63) | PLAUKLK8KLK4KLK2 | |
| SCHEMBL5901034 | 0.78 | MRGPRX1 (0.48) | PLAUKLK8KLK4KLK2F2 | |
| SCHEMBL16239049 | 0.78 | KLK8 (0.55) | PLAUKLK8KLK4KLK2 | |
| SCHEMBL2242403 | 0.77 | PLAU (0.67) | PLAUKLK8KLK4KLK2F2 | |
| SCHEMBL4231397 | 0.76 | KLK8 (0.59) | PLAUKLK8KLK4KLK2 | |
| SCHEMBL916422 | 0.76 | KLK8 (0.59) | PLAUKLK8KLK4KLK2 | |
| SCHEMBL29267239 | 0.76 | KLK8 (0.59) | PLAUKLK8KLK4KLK2 | |
| SCHEMBL916048 | 0.74 | KLK8 (0.57) | PLAUKLK8KLK4KLK2 | |
| SCHEMBL28701098 | 0.74 | KLK8 (0.57) | PLAUKLK8KLK4KLK2PKM | |
| SCHEMBL6766317 | 0.72 | KLK8 (0.55) | PLAUKLK8KLK4KLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |