Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 1.00 |
| ▸ | CNR2 | P34972 | 2/20 | 0.77 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.58 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511967 | 1.00 | CNR1 (1.00) | CNR1CNR2TAS1R3TAS1R1HTT | |
| SCHEMBL6515255 | 0.87 | CNR1 (1.00) | CNR1CNR2TAS1R3TAS1R1HTT | |
| SCHEMBL3390949 | 0.87 | CNR1 (1.00) | CNR1CNR2TAS1R3TAS1R1HTT | |
| SCHEMBL12788196 | 0.79 | SMN1; SMN2 (0.69) | CNR1HTTALDH1A1HPGDNPSR1 | |
| SCHEMBL5613910 | 0.78 | CNR1 (0.66) | CNR1CNR2TAS1R3TAS1R1HTT | |
| SCHEMBL6511965 | 0.78 | CNR1 (0.64) | CNR1CNR2HTTALDH1A1HPGD | |
| SCHEMBL3395386 | 0.78 | CNR1 (0.64) | CNR1CNR2HTTALDH1A1HPGD | |
| SCHEMBL14335869 | 0.78 | CNR1 (0.69) | CNR1CNR2TAS1R3TAS1R1HTT | |
| SCHEMBL14184701 | 0.77 | CNR1 (0.66) | CNR1CNR2TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL3395117 | 0.76 | CNR1 (0.75) | CNR1CNR2TAS1R3TAS1R1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370530-B1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-12-29 | — | — | EP | disclosed |
| EP-1370530-A1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | Aventis Pharma Deutschland GmbH (DE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002064565-A1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-08-22 | — | — | WO | disclosed |