Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395452 | 1.00 | CYP26A1 (0.42) | CYP26A1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL22462730 | 0.91 | ABCB1 (0.41) | ALDH1A1 | |
| SCHEMBL598931 | 0.89 | BRD4 (0.42) | CYP26A1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL598932 | 0.89 | BRD4 (0.42) | CYP26A1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL12518938 | 0.88 | ABCB1 (0.44) | CYP26A1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL13717031 | 0.88 | ABCB1 (0.44) | CYP26A1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL598349 | 0.85 | HCRTR1 (0.39) | CYP26A1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL598350 | 0.85 | HCRTR1 (0.39) | CYP26A1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8181740 | 0.84 | HCRTR1 (0.38) | CYP26A1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL16014894 | 0.84 | ALDH1A1 (0.38) | RAB9ASMN1; SMN2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105061314-A | Neprilysin inhibitors | THERAVANCE INC | 2015-11-18 | — | — | CN | disclosed |
| CN-103261164-B | Enkephalinase inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-19 | — | — | CN | disclosed |
| CN-103261164-A | Enkephalinase inhibitors | THERAVANCE INC | 2013-08-21 | — | — | CN | disclosed |
| EP-2245009-A2 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 5-BIPHENYL-4-YL-2-METHYLPENTANOIC ACID DERIVATIVES | Novartis AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009090251-A2 | NEW PROCESSES | NOVARTIS AG (CH) | 2009-07-23 | — | — | WO | disclosed |