Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 5/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18255975 | 1.00 | TRPV1 (0.42) | TRPV1HTTF10F2SIGMAR1 | |
| SCHEMBL3423065 | 1.00 | TRPV1 (0.42) | TRPV1HTTF10F2SIGMAR1 | |
| SCHEMBL18255966 | 1.00 | TRPV1 (0.42) | TRPV1HTTF10F2SIGMAR1 | |
| SCHEMBL3400557 | 0.93 | HTT (0.43) | TRPV1HTTF10F2SIGMAR1 | |
| SCHEMBL3427823 | 0.93 | HTT (0.43) | TRPV1HTTF10F2SIGMAR1 | |
| SCHEMBL633751 | 0.85 | SIGMAR1 (0.41) | TRPV1SIGMAR1 | |
| SCHEMBL633752 | 0.85 | SIGMAR1 (0.41) | TRPV1SIGMAR1 | |
| SCHEMBL16469444 | 0.83 | SIGMAR1 (0.41) | F10SIGMAR1 | |
| SCHEMBL16469443 | 0.83 | SIGMAR1 (0.41) | F10SIGMAR1 | |
| SCHEMBL633033 | 0.82 | HTT (0.38) | HTTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505750-B2 | 5-aminocyclylmethyl-oxazolidin-2-one derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-11-29 | — | — | US | claimed |
| US-9505750-B2 | 5-aminocyclylmethyl-oxazolidin-2-one derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-11-29 | — | — | US | disclosed |
| EP-2245028-A1 | 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009077989-A1 | 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-06-25 | — | — | WO | disclosed |