Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3427823 | 1.00 | HTT (0.43) | HTTSIGMAR1TRPV1ALDH1A1LMNA | |
| SCHEMBL3395582 | 0.93 | TRPV1 (0.42) | HTTSIGMAR1TRPV1F2F10 | |
| SCHEMBL18255975 | 0.93 | TRPV1 (0.42) | HTTSIGMAR1TRPV1F2F10 | |
| SCHEMBL18255966 | 0.93 | TRPV1 (0.42) | HTTSIGMAR1TRPV1F2F10 | |
| SCHEMBL3423065 | 0.93 | TRPV1 (0.42) | HTTSIGMAR1TRPV1F2F10 | |
| SCHEMBL633034 | 0.87 | HTT (0.38) | HTTSIGMAR1ALDH1A1LMNA | |
| SCHEMBL633033 | 0.87 | HTT (0.38) | HTTSIGMAR1ALDH1A1LMNA | |
| SCHEMBL592114 | 0.85 | HTT (0.47) | HTTTRPV1ALDH1A1LMNAPOLB | |
| SCHEMBL592115 | 0.85 | HTT (0.47) | HTTTRPV1ALDH1A1LMNAPOLB | |
| SCHEMBL16469444 | 0.84 | SIGMAR1 (0.41) | SIGMAR1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505750-B2 | 5-aminocyclylmethyl-oxazolidin-2-one derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-11-29 | — | — | US | claimed |
| US-9505750-B2 | 5-aminocyclylmethyl-oxazolidin-2-one derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-11-29 | — | — | US | disclosed |
| EP-2245028-A1 | 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009077989-A1 | 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-06-25 | — | — | WO | disclosed |