Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 0.64 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 7/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28111934 | 0.83 | TUBB1 (0.72) | TUBB1NFE2L2PTGS1APPCYP1A1 | |
| SCHEMBL3393526 | 0.81 | APP (0.55) | TUBB1NFE2L2PTGS1APPCYP1A1 | |
| SCHEMBL18003049 | 0.81 | TUBB1 (0.64) | TUBB1NFE2L2PTGS1APPCYP1A1 | |
| SCHEMBL14104820 | 0.80 | TUBB1 (0.77) | TUBB1NFE2L2PTGS1CYP1A1CYP1A2 | |
| SCHEMBL17822001 | 0.78 | TUBB1 (0.69) | TUBB1NFE2L2PTGS1APPCYP1A1 | |
| SCHEMBL17822004 | 0.78 | TUBB1 (0.69) | TUBB1NFE2L2PTGS1APPCYP1A1 | |
| SCHEMBL10069721 | 0.77 | TUBB1 (0.62) | TUBB1NFE2L2PTGS1APPCYP1A1 | |
| SCHEMBL5491899 | 0.77 | RELA (0.71) | TUBB1NFE2L2PTGS1APPCYP1A1 | |
| SCHEMBL5491895 | 0.77 | RELA (0.71) | TUBB1NFE2L2PTGS1APPCYP1A1 | |
| SCHEMBL13972632 | 0.76 | TUBB1 (0.71) | TUBB1NFE2L2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |