Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.56 |
| ▸ | JAK2 | O60674 | 3/20 | 0.56 |
| ▸ | JAK1 | P23458 | 2/20 | 0.56 |
| ▸ | TYK2 | P29597 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL352896 | 0.80 | JAK1 (0.73) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL10062083 | 0.80 | JAK1 (0.73) | JAK3JAK2JAK1TYK2 | |
| Hydrochloric Acid SCHEMBL2105371 | 0.79 | JAK3 (0.56) | JAK3JAK2JAK1TYK2ACHE | |
| SCHEMBL9920437 | 0.78 | JAK2 (0.50) | JAK3JAK2JAK1TYK2ACHE | |
| SCHEMBL17718758 | 0.76 | ACHE (0.57) | JAK3JAK2JAK1TYK2ACHE | |
| SCHEMBL2320056 | 0.76 | ACHE (0.57) | JAK3JAK2JAK1TYK2ACHE | |
| SCHEMBL20624405 | 0.75 | ACHE (0.55) | JAK3JAK2JAK1TYK2ACHE | |
| SCHEMBL18559428 | 0.73 | JAK2 (0.44) | JAK3JAK2JAK1TYK2KCNH2 | |
| SCHEMBL9918648 | 0.73 | JAK3 (0.61) | JAK3JAK2JAK1TYK2ACHE | |
| SCHEMBL1847730 | 0.71 | JAK3 (0.62) | JAK3JAK2JAK1TYK2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251341-A1 | Heterocyclic Janus kinase 3 inhibitors | Astellas Pharma Inc. (JP) | 2010-11-17 | — | — | EP | disclosed |